HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Cyclopropyl-3-oxopropanenitrile → Quinoline-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Cyclopropyl-3-oxopropanenitrile | HCID 9812763 | — |
| Reactant | 2-Amino-4'-fluorobenzophenone | HCID 9837287 | — |
| Product | Quinoline-2-carbonitrile | HCID 74031 | — |
Reaction Steps
The cyclization reaction step of the present invention is a step of reacting 3-cyclopropyl-3-oxopropanenitrile of the formula (1) with 2-amino-4′-fluorobenzophenone of the formula (2) preferably in the presence of an acid to obtain a quinolinecarbonitrile derivative [2-cyclopropyl-4-(4′-fluorophenyl)quinoline-3-carbonitrile] of the formula (3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06841681B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-fcb79a81fc7d4ba79d80b4b37e899127 |
| Source note | uspto-grants-2005_01 |