2-Aminophenol → HCID 23106862, compound

HRID 1782553

Reaction equation

HRID 1782553 reaction equation
I[CH:2]([CH2:4][CH2:5][CH2:6][CH3:7])[CH3:3].[NH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15]>>[CH3:3][CH:2]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15])[CH2:4][CH2:5][CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 58012-Aminophenol2×HCID 330192-Iodohexane2×

Product 1

HCID 23106862HCID 23106862, compound

Procedure

The same procedure as in Example 6 was repeated except that the molar ratio of 2-iodohexane to o-aminophenol was changed to 0.8, the 2-iodohexane was dropped over 4.5 h, and then the reaction mixture was stirred at room temperature for 0.5 h. As a result, it was confirmed that the rate of conversion of o-aminophenol was 71%, the selectivity to the N-monoalkylated compound was 86%, and the oxygen absorption initiation time as an index of determining an oxidation-inhibiting property thereof was 320 min.

Workup

  1. customthe oxygen absorption initiation time as an index
  2. waitthereof was 320 min.

Sources & evidence

ORD record
ord-25de0d922c614920bc11e2d755fc570c
Source dataset
uspto-grants-2009_03
Patent number
US07498467B2

Linked notes

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