Sulfuryl chloride → Bis-(2-fluorophenyl)disulfide

HRID 1802854

Reaction equation

HRID 1802854 reaction equation
S(Cl)(Cl)(=O)=O.[F:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[SH:13]>C(Cl)Cl>[F:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13][S:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[F:6]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 5202162-Fluorothiophenol

Product 1

HCID 14740277Bis-(2-fluorophenyl)disulfide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Sulfuryl chloride (0.7 ml) was added dropwise to a solution of 2-fluorobenzenethiol (1.5 ml) in DCM (20 ml) at 0° C. The reaction mixture was stirred for 30 min, then concentrated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane to give the sub-title compound as an oil, yield 1.7 g.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was purified by chromatography on silica eluting with isohexane

Sources & evidence

ORD record
ord-ee5316fd6ad8436ba224b5d5b9cead2a
Source dataset
uspto-grants-2013_01
Patent number
US08349897B2

Linked notes

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