HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azidotrimethylsilane → [[1-(4-Chloro-benzyl)-1H-tetrazol-5-yl]-(1H-indol-5-yl)-methyl]-(3-imidazol-1-yl-propyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azidotrimethylsilane | HCID 78378 | — |
| Reactant | 1H-Imidazole-1-propanamine | HCID 78736 | — |
| Reactant | Indole-5-carboxaldehyde | HCID 589040 | — |
| Reactant | 1-Chloro-4-(isocyanomethyl)benzene | HCID 2757409 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [[1-(4-Chloro-benzyl)-1H-tetrazol-5-yl]-(1H-indol-5-yl)-methyl]-(3-imidazol-1-yl-propyl)-amine | HCID 59345367 | — |
Reaction Steps
3-Imidazol-1-yl-propylamine (1 mmol) and 1H-Indole-5-carbaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and 1-Chloro-4-isocyanomethyl-benzene (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07741354B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-f940c1933ff04e1d9ae29bae6ac77221 |
| Source note | uspto-grants-2010_06 |