2,5-Dimethyl-2H-pyrazole-3-carbonyl chloride → N-[2-chloro-5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

Participants

Reaction Steps

In the same manner as in Example 24 and using 1,3-dimethyl-1H-pyrazole-5-carbonyl chloride (89.2 mg, 0.562 mmol), N,N-dimethylacetamide (5 mL) and N-[6-(3-amino-4-chlorophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (170 mg, 0.495 mmol) as starting materials, the title compound (92.2 mg, 40%) was obtained as a white solid.

Provenance & Evidence