4-(Piperazin-1-yl)benzonitrile → 4-[4-(2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetyl)-piperazin-1-yl]-benzonitrile

Participants

Reaction Steps

In a manner analogous to the method described in examples 99, {4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochloride (example 94) was coupled with 4-piperazin-1-yl-benzonitrile (Fluka) to give the title compound. HR-MS (ES, m/z) calculated for C46H53Cl2N8O3 [(M+H)+] 835.3612, observed 835.3611.

Provenance & Evidence