HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 19608Generated: October 24, 2026
tert-Butyl (4-aminophenyl)carbamate → {4-[5-(6-Benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenyl}-carbamic acid tert-butyl ester
https://huagongshe.com/en/reaction/19608
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butyl (4-aminophenyl)carbamate | HCID 688611 | — |
| Reactant | 5-(6-Benzyloxy-naphthalen-2-yl)-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine | HCID 67319776 | — |
| Product | {4-[5-(6-Benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenyl}-carbamic acid tert-butyl ester | HCID 67319245 | 46% |
Reaction Steps
A mixture of 5-(6-benzyloxy-naphthalen-2-yl)-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine (compound D2)(87 mg) and 4-amino-phenyl-carbamic acid tert-butyl ester (208 mg) is heated neat at 130 to 140° C. bath temperature for 20 min. After cooling, the crude product is purified by silica gel flash chromatography. A nearly colorless solid (51 mg, 46%) with melting temperature of 189° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07745446B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-511010926b6f4983a5ba276bd9effa2d |
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| Source note | uspto-grants-2010_06 |
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