HCID 36845230, compound → N-methyl-2-piperazin-1-ylacetamide

HRID 1972727

Reaction equation

HRID 1972727 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([NH:17][CH3:18])=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CCO>[CH3:18][NH:17][C:15](=[O:16])[CH2:14][N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 36845230HCID 36845230, compound

Product 1

HCID 4962075N-methyl-2-piperazin-1-ylacetamideYield 98.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

10% Palladium on carbon (115 mg, 10% by wt.) was placed under an inert atmosphere and suspended in EtOH (5 mL). A solution of 2-(4-benzyl-piperazin-1-yl)-N-methyl-acetamide (1.15 g, 4.65 mmol) dissolved in EtOH (18 mL) was added. The reaction mixture was placed under H2 atmosphere (1 Atm pressure) and stirred overnight. The resulting mixture was filtered through a pad of Celite® and the solvent was concentrated in vacuo to give 723 mg (98.9%) of the title compound as a white solid. 1H-NMR (300 MHz, DMSO-d6) 7.61 (broad s, 1H), 2.80 (s, 2H), 2.68 (t, 4H), 2.59 (d, 3H), 2.31 to 2.26 (m, 4H); ES-MS m/z 158.0 [M+H]+, RT (min) 1.13.

Workup

  1. additionwas added
  2. filtrationThe resulting mixture was filtered through a pad of Celite®
  3. concentrationthe solvent was concentrated in vacuo

Sources & evidence

ORD record
ord-831faa8a6f864fac96be13c9251261ac
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Linked notes

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