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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2000204Generated: October 24, 2026

Benzylamine → tert-butyl (3R,4R)-4-(benzylamino)-3-hydroxypiperidine-1-carboxylate

https://huagongshe.com/en/reaction/2000204

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzylamineHCID 7504—
Reactanttert-butyl (1S,6R)-7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylateHCID 55273474—
ReagentGallium chlorideHCID 26010—
SolventEthanolHCID 702—
Producttert-butyl (3R,4R)-4-(benzylamino)-3-hydroxypiperidine-1-carboxylateHCID 67335553—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-ce8ca0888efe4aa6b5bd1c2498cd76c0
Source note39k HTE dataset from Pfizer