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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2065602Generated: October 23, 2026

L-(-)-Tryptophanol → 6-Chloro-2-[(S)-1-hydroxymethyl-2-(1H-indol-3-yl)-ethylamino]-quinoline-3-carboxylic acid

https://huagongshe.com/en/reaction/2065602

Reaction equation

Participants

RoleNameHCIDCharge
ReactantL-(-)-TryptophanolHCID 6951149—
Reactant2,6-Dichloroquinoline-3-carboxylic acidHCID 24266068—
Product6-Chloro-2-[(S)-1-hydroxymethyl-2-(1H-indol-3-yl)-ethylamino]-quinoline-3-carboxylic acidHCID 4525705973%

Reaction Steps

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with L-tryptophanol to provide the title compound in 73% yield as yellow needles (recrystallization from EtOH).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08288549B2
Source datasetuspto-grants-2012_10
ORD IDord-680c388c44044c8ea031615f829d84c2
Source noteuspto-grants-2012_10