Ethanolamine → HCID 21408176, compound

HRID 2072386

Reaction equation

HRID 2072386 reaction equation
[C:1]([C:4]1[CH:9]=[N+:8]([O-:10])[C:7]([CH3:11])=[CH:6][N:5]=1)([OH:3])=[O:2].C(CN)O>CO>[CH2:1]([CH2:4][NH2:5])[OH:2].[C:1]([C:4]1[CH:9]=[N+:8]([O-:10])[C:7]([CH3:11])=[CH:6][N:5]=1)([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 5310993Acipimox

Product 1

HCID 21408176HCID 21408176, compoundYield 120.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Carboxy-5-methylpyrazine 4-oxide (2.5 g) was added to methanol (60 ml) and ethanolamine (1.1 ml). The mixture was refluxed for 20 minutes, then cooled and filtered to obtain 2-carboxy-5-methylpyrazine 4-oxide ethanolamine salt (2.1 g), m.p. 177°-180° C, after crystallisation from methanol.

Workup

  1. temperatureThe mixture was refluxed for 20 minutes
  2. temperaturecooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-d0005dc3fa04492e93be2da5511f0b34
Source dataset
uspto-grants-1977_09
Patent number
US04051245

Linked notes

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