Sodium Hydroxide → HCID 22724875, compound

HRID 2086562

Reaction equation

HRID 2086562 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11][C:12](=[O:24])/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=1)=[O:4].[OH-].[Na+]>CO>[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11][C:12](=[O:24])/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=1)([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 692365methyl 2-[(2E)-3-(3-nitrophenyl)prop-2-enoylamino]benzoate

Product 1

HCID 22724875HCID 22724875, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

500 mg (1.53 mmol) of trans-3-nitrocinnamic acid-N-(2-methoxycarbonyl-phenyl)-amide are stirred into a mixture of 20 ml of methanol and 8 ml of 2N sodium hydroxide solution for two hours at 50° C. Then the methanol is distilled off in vacuo, the residue is diluted with about 150 ml of water and adjusted to about pH 2.5 with stirring. The product which is then precipitated is suction filtered, washed with about 10 ml of water and dried.

Workup

  1. distillationThen the methanol is distilled off in vacuo
  2. additionthe residue is diluted with about 150 ml of water
  3. customThe product which is then precipitated
  4. filtrationfiltered
  5. washwashed with about 10 ml of water
  6. customdried

Sources & evidence

ORD record
ord-6ed9cdad5340498287da76fd7f799bf4
Source dataset
uspto-grants-2004_04
Patent number
US06727250B2

Linked notes

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