HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-chloro-4-fluoro-N-(1-methyl-1-phenylethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cumylamine | HCID 68509 | — |
| Reactant | 3-Chloro-4-fluorobenzoyl Chloride | HCID 2736548 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-chloro-4-fluoro-N-(1-methyl-1-phenylethyl)benzamide | HCID 68491942 | 97.1% |
Reaction Steps
In a similar manner to Step 1 of Example 16, 3-chloro-4-fluorobenzoyl chloride (3.00 g, 15.5 mmol) was dissolved in dichloromethane (60 mL), and the solution was treated with cumylamine (2.45 mL, 17.1 mmol), triethylamine (3.24 mL, 23.3 mmol) and DMAP (189 mg, 1.05 mmol), followed by purification by slurry using diisopropylether to obtain 3-chloro-4-fluoro-N-(1-methyl-1-phenylethyl)benzamide (4.39 g, yield 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745641B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-ffb7690b8cdc47748458e2379a0e394f |
| Source note | uspto-grants-2010_06 |