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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 218621Generated: October 24, 2026

6,7,8,9-tetrahydro-5H-benzo(7)annulene-5-carboxylic acid → N-[(1-ethylpyrazol-4-yl)methyl]-N-(4-isopropylphenyl)-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-carboxamide

https://huagongshe.com/en/reaction/218621

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6,7,8,9-tetrahydro-5H-benzo(7)annulene-5-carboxylic acidHCID 14822604—
ReactantN-((1-Ethyl-1H-pyrazol-4-yl)methyl)-4-isopropylanilineHCID 21957909—
ProductN-[(1-ethylpyrazol-4-yl)methyl]-N-(4-isopropylphenyl)-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-carboxamideHCID 1785419657%

Reaction Steps

By the reaction and treatment in the same manner as in Example 12 using 6,7,8,9-tetrahydro-5H-benzocycloheptene-5-carboxylic acid (0.29 g) and [(1-ethylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.37 g) as starting materials, N-[(1-ethylpyrazol-4-yl)methyl]-N-(4-isopropylphenyl)-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-carboxamide (0.36 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08198454B2
Source datasetuspto-grants-2012_06
ORD IDord-40128212572a4fbe8a6381a6bddd6a03
Source noteuspto-grants-2012_06