HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanogen Bromide → 2-Aminobenzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Methoxybenzene-1,2-diamine | HCID 184268 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Aminobenzimidazole | HCID 13624 | — |
Reaction Steps
Cyanogen bromide (7.05 mmol, 0.74 g) was added to a solution of 2,3-diaminoanisole (4.7 mmol, 0.65 g) in EtOH (10 mL) and the reaction was stirred at room temperature for 14 h. The reaction was diluted with H2O and then basified (pH>12) using 4 M NaOH. The aqueous layer was extracted with CH2Cl2. The organic phase was then separated and washed with brine and then dried over MgSO4 and then concentrated to provide 2-aminobenzimidazole 37b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207173B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-4dd7d82b92d54646aeddc463d3d6f37d |
| Source note | uspto-grants-2012_06 |