Benzaldehyde, 3,5-dimethyl- → HCID 59390145, compound

HRID 2358503

Reaction equation

HRID 2358503 reaction equation
[C:1]1([P:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:8][CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][C:18]1[CH:19]=[C:20]([CH:23]=[C:24]([CH3:26])[CH:25]=1)[CH:21]=O>C(O)C>[CH3:17][C:18]1[CH:25]=[C:24]([CH:26]=[N:10][CH2:9][CH2:8][P:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:23]=[C:20]([CH3:21])[CH:19]=1

Participants

4

Reactant 2

HCID 34225Benzaldehyde, 3,5-dimethyl-HCID 273264(2-Aminoethyl)diphenylphosphine

Product 1

HCID 59390145HCID 59390145, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Under argon, a solution of 2-diphenylphosphino-ethylamine (652.2 mg, 2.84 mmol) and 3,5-dimethyl-benzaldehyde (387.4 mg, 2.89 mmol) in ethanol (15 mL) was heated at 65° C. (oil bath) for 4 h. Then, the solvent was removed in-vacuo to give the desired product (>98% by 1H-NMR) as a colourless oil (993.2 mg, 2.8 mmmol, quantitative).

Workup

  1. customThen, the solvent was removed in-vacuo

Sources & evidence

ORD record
ord-cfa24e65e3b74f51aca3b505b58e1af8
Source dataset
uspto-grants-2010_07
Patent number
US07763758B2

Linked notes

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