4-Amino-2,6-dibromophenol → HCID 69274007, compound

HRID 2375426

Reaction equation

HRID 2375426 reaction equation
[C:1]([CH:4]([CH2:10][C:11](=O)[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6])(=O)[CH3:2].[Br:14][C:15]1[CH:20]=[C:19]([NH2:21])[CH:18]=[C:17]([Br:22])[C:16]=1[OH:23]>CCO>[Br:14][C:15]1[CH:20]=[C:19]([N:21]2[C:11]([CH3:12])=[CH:10][C:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])=[C:1]2[CH3:2])[CH:18]=[C:17]([Br:22])[C:16]=1[OH:23]

Participants

4

Reactant 2

HCID 691074-Amino-2,6-dibromophenolHCID 3084847Ethyl 2-acetyl-4-oxovalerate

Product 1

HCID 69274007HCID 69274007, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Utilizing the procedure outlined in Example 85, ethyl 2-acetyl-4-oxopentanoate (6.37 g, 34.2 mmol) was dissolved in 20 mL of EtOH. 2,6-dibromo-4-aminophenol (11.6g, 34.2mmol) were reacted to afford ethyl 1-(3,5-dibromo-4-hydroxyphenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate was taken on without further purification. MS (ESI) 418 (M+H)+.

Sources & evidence

ORD record
ord-d3768bf0effa473a8e30a37b8c51e892
Source dataset
uspto-grants-2008_12
Patent number
US07465730B2

Linked notes

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