HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-(ethylsulfonyl)pyridine → [4-(5-Ethanesulfonyl-pyridin-2-yloxy)-3,6-difluoro-naphthalen-2-yl]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-(ethylsulfonyl)pyridine | HCID 53393184 | — |
| Reactant | (3,6-Difluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester | HCID 59326617 | — |
| Reactant | 2-(4-Fluoro-benzylidene)-succinic acid 1-methyl ester | HCID 67303799 | — |
| Product | [4-(5-Ethanesulfonyl-pyridin-2-yloxy)-3,6-difluoro-naphthalen-2-yl]-acetic acid methyl ester | HCID 59326477 | 48% |
Reaction Steps
Starting with (3,6-difluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester (25 mg, 0.099 mmol) and 2-bromo-5-ethanesulfonyl-pyridine (28 mg, 0.112 mmol), using a method analogous to the one described for the methyl ester of example 1-1, [4-(5-ethanesulfonyl-pyridin-2-yloxy)-3,6-difluoro-naphthalen-2-yl]-acetic acid methyl ester (20 mg, 48%) was obtained as a white solid, which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642629B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-1ba199307a4f4c2e99abaff2eacf5524 |
| Source note | uspto-grants-2014_02 |