HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetaldehyde, 2,2-dimethoxy- → N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetaldehyde, 2,2-dimethoxy- | HCID 162650 | — |
| Reactant | 4-Fluoro-3-methoxyaniline | HCID 2774533 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline | HCID 22570019 | 101.1% |
Reaction Steps
To a solution of 4-fluoro-3-methoxyaniline (0.98 g 6.9 mmol) in ethanol (20 ml) was added glyoxal 1,1-dimethyl acetal (0.89 g 8.27 mmol). Pd/C 5% (50 mg) was added and the mixture hydrogenated. Removal of the catalyst by filtration and evaporation of solvent in vacuo gave N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline 1.6 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06855715B1 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-a5bf9884b51f40babe1c53423ffc7dc7 |
| Source note | uspto-grants-2005_02 |