HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-(2,2-dimethoxyethyl)-N-methanesulphonyl-4-fluoro-3-methoxyaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline | HCID 22570019 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2,2-dimethoxyethyl)-N-methanesulphonyl-4-fluoro-3-methoxyaniline | HCID 22570034 | 97.6% |
Reaction Steps
N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline (1.46 g, 6.37 mmol) in dichloromethane (20 ml) was treated with pyridine (0.5 g 6.37 mmol) and methanesulphonyl chloride (766 mg, 6.69 mmol) and the mixture stirred until the reaction was complete by tlc. Aqueous work up and removal of solvent in vacuo gave N-(2,2-dimethoxyethyl)-N-methanesulphonyl-4-fluoro-3-methoxyaniline 1.91 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06855715B1 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-f7292c86d35d44d4acc5a0008826e6a7 |
| Source note | uspto-grants-2005_02 |