HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(-)-1-Amino-2-(methoxymethyl)pyrrolidine → 5-cyclohexyl-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(-)-1-Amino-2-(methoxymethyl)pyrrolidine | HCID 7156993 | — |
| Reactant | 5-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid | HCID 71293952 | — |
| Product | 5-cyclohexyl-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxamide | HCID 71294024 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid (example 12c) and (2S)-2-(methoxymethyl)-1-pyrrolidinamine (CAN 59983-39-0) as starting materials; LC-MS (UV peak area/ESI) 98.8%, 416.2159 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648099B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-83f31f3ac5054a288462c3779695004d |
| Source note | uspto-grants-2014_02 |