HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-[(3S)-piperidin-3-yl]carbamate → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-[(3S)-piperidin-3-yl]carbamate | HCID 1514171 | — |
| Reactant | 4-Chloroisoquinoline-5-sulfonyl chloride | HCID 22121908 | — |
| Product | Hydrochloric Acid | HCID 313 | 1,932.7% |
| Product | (S)-3-(tert-Butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67243279 | — |
| Product | (S)-3-Amino-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67244043 | — |
Reaction Steps
(S)-3-(tert-Butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)piperidine (Intermediate 18a) was prepared from 4-chloro-5-isoquinolinesulfonyl chloride (183 mg) and (S)-3-(tert-butoxycarbonylamino)piperidine (168 mg) according to the method described in Example 1-1, Step A, and then used in the method of Example 1-1, Step B in a similar manner to obtain the title compound as hydrochloride (164 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964613B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-bb60318ce6f74dcd96712840fb833ba6 |
| Source note | uspto-grants-2011_06 |