HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-methylnicotinic acid → 3-[1,2,3]Triazol-2-yl-pyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-methylnicotinic acid | HCID 121724 | — |
| Reactant | 3-Bromopyridine-2-carboxylic Acid | HCID 2050129 | — |
| Reactant | 6-Methyl-2-[1,2,3]triazol-2-yl-nicotinic acid | HCID 67086855 | — |
| Product | 3-[1,2,3]Triazol-2-yl-pyridine-2-carboxylic acid | HCID 66742288 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 70 substituting 3-bromo-2-pyridinecarboxylic acid for 2-chloro-6-methylnicotinic acid. MS (ESI): mass calculated for C8H6N4O2, 190.10; m/z found 191.1 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.77 (d, J=4.3 Hz, 1H), 8.26 (dt, J=6.5, 3.3 Hz, 1H), 7.88 (s, 2H), 7.65 (dd, J=8.2, 4.7 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653263B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-118dfbd8519d4f50923d0036be63e290 |
| Source note | uspto-grants-2014_02 |