HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | tert-Butyl 3-methyl-5-nitro-1H-indazole-1-carboxylate | HCID 22567205 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate | HCID 59276571 | 89% |
Reaction Steps
5-Amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole can be obtained as described in Example 6 from 3.4 g of N-tert-butoxycarbonyl-3-methyl-5-nitro-1H-indazole, 50 ml of methanol, 0.61 g of 10% palladium-on-charcoal and 3.53 g of ammonium formate. 2.7 g of 5-amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole are thus obtained in the form of a cream solid melting at 185° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06858638B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-fcdd43b1809b47dfab16fdca94887db9 |
| Source note | uspto-grants-2005_02 |