HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 4-(4-Methylphenyl)-4-oxobutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Product | 4-(4-Methylphenyl)-4-oxobutanoic acid | HCID 244162 | 75% |
Reaction Steps
Toluene 10b (99.9%, 5.5 eq) was reacted with succinic anhydride (99%, 1 eq) and AlCl3 (95%, 2 eq) for 24 h according to the general procedure. Yellow crystals of 11b were obtained in 75% yield. 1H-NMR: 7.88 (d, 2H, J=8.2 Hz, Ar--H); 7.26 (d, 2H, J=4.8 Hz, Ar--H); 3.29 (t, 2H, J=6.6 Hz, CH2CH2COOH); 2.80 (t, 2H, J=6.6 Hz, CH2CH2COOH); 2.41 (s, 3H, CH3). 13C-NMR: 192.44; 178.70; 144.13; 133.91; 129.29; 128.14; 33.02; 28.06; 21.63.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05525736 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-eedb300dd053411aa31b470247cd67c7 |
| Source note | uspto-grants-1996_06 |