HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 261069Generated: October 23, 2026
Oxalic Acid → 5-(2-Hydroxy-5-nitro-benzyl)-6-methyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine
https://huagongshe.com/en/reaction/261069
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 6-Methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | HCID 20321991 | — |
| Reactant | HCID 178486302 | HCID 178486302 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(2-Hydroxy-5-nitro-benzyl)-6-methyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine | HCID 20396037 | 27% |
Reaction Steps
A mixture of 6-methyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine (6.3 g; 41 mmoles), p-nitro-phenol (5.7 g; 41 mmoles), polyoxymethylene (2.5 g; 83 mmoles) and dioxan (50 cc) is stirred at 80° C. during 4 hours. After concentration in vacuo, the residue is dissolved in ether and then treated with 0.5 equivalent oxalic acid in ethanol solution. The resulting semi-oxalate is filtered, washed with boiling methanol-water (1:3), filtered again and dried (M.p.= 214° C.; yield: 27%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04163852 |
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| Source dataset | uspto-grants-1979_08 |
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| ORD ID | ord-3d13a2696d7346819c9049d84c7ccdfa |
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| Source note | uspto-grants-1979_08 |
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