HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-Vanillin → 3-Methoxy-2-[3-(4-morpholinyl)propoxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-Vanillin | HCID 8991 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(3-Chloropropyl)morpholine | HCID 95834 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Methoxy-2-[3-(4-morpholinyl)propoxy]benzaldehyde | HCID 2200348 | — |
Reaction Steps
o-Vanillin (30.4 g), dissolved in 160 ml of dimethylformamide, is treated with 9.6 g of 50% sodium hydride, then with 130 ml of 2 N N-(3-chloropropyl)morpholine in toluene following the procedure described in Example 1A, yielding 42.9 g of the title compound, boiling point 178°-183° C. at 0.2-0.3 mm of Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04156079 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-92248dd455be49e5bd27abe69f04c771 |
| Source note | uspto-grants-1979_05 |