HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-1-butyne → 2,4-Diamino-5-[3,4-dimethoxy-5-(1-methyl-2-propynyloxy)benzyl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-1-butyne | HCID 30443 | — |
| Reactant | 3-Demethyltrimethoprim | HCID 12849769 | — |
| Product | 2,4-Diamino-5-[3,4-dimethoxy-5-(1-methyl-2-propynyloxy)benzyl]pyrimidine | HCID 12849802 | 62% |
Reaction Steps
The title compound was prepared in 62% yield from 2,4-diamino-5-(3-hydroxy-4,5-dimethoxybenzyl)pyrimidine and 3-chloro-1-butyne by the procedure of Example 1A. Crystallization from methanol gave white solid; mp 153°-155°. Anal. Calcd for C17H20N4O3 : C, 62.18; H, 6.14; N, 17.06. Found: C, 61.93; H, 6.22; N, 16.98.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04587342 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-1f4067bd24644e1ea1473f23c7fb53bd |
| Source note | uspto-grants-1986_05 |