6-Methoxy-2-naphthaldehyde → 1-(1-(3-Chlorophenyl)-2-[4-[(6-methoxy-2-naphthyl)methyl]piperazin-1-yl]ethyl)cyclohexanol dihydrochloride

Participants

Reaction Steps

A solution of 1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol (see Example 1) (200 mg, 0.62 mmol) and 6-methoxy-2-napthaldehyde (173 mg, 0.93 mmol) in dichloroethane (4 mL) was treated with sodium trisacetoxyborohydride (195 mg, 0.92 mmol). The reaction was placed on a shaker and where it was stirred for 16 h. The reaction was then washed with a 2 N aqueous solution of hydrochloric acid (2×2 mL), and the organic layer was stored at 25° C. for 16 h. The resulting precipitate was collected, washed with diethyl ether and dried in vacuo to yield 194 mg (64%) 1-(1-(3-chlorophenyl)-2-{4-[(6-methoxy-2-naphthyl)methyl]piperazin-1-yl}ethyl)cyclohexanol dihydrochloride as a white solid. MS (ESI) m/z 493/495 ([M+H]+); HRMS: calcd for C30H37ClN2O2.2.00 HCl, 564.2077; found (ESI_FT), 493.2632.

Provenance & Evidence