HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 323213Generated: October 24, 2026
Hydrogen Bromide → (1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydriodic acid
https://huagongshe.com/en/reaction/323213
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | 1-Piperidinecarboxylic acid, 4-(1H-benzimidazol-2-ylamino)-, ethyl ester | HCID 3018455 | — |
| Product | (1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydriodic acid | HCID 86754231 | — |
Reaction Steps
Combine (1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine (4.63 g, 16 mmol) and 48% hydrobromic acid (75 mL). Heat to reflux. After 1.5 hours, cool and evaporate in vacuo to give a solid. Add 47% hydriodic acid (30 mL) and heat at about 90° C. After 30 minutes cool to obtain a solid. Collect the solid by filtration, rinse with ethanol and diethyl ether, and dry to give the title compound: mp; >290° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06211199B1 |
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| Source dataset | uspto-grants-2001_04 |
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| ORD ID | ord-97691acebaf24ddab33abb9408c6041d |
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| Source note | uspto-grants-2001_04 |
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