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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 326039Generated: October 24, 2026

Ethyl 2-(4-hydroxyphenoxy)-2-methylpropanoate → Ethyl 2-methyl-2-[4-(6-chloroquinolin-2-yloxy)phenoxy]-propionate

https://huagongshe.com/en/reaction/326039

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-(4-hydroxyphenoxy)-2-methylpropanoateHCID 181741—
Reactant2,6-DichloroquinolineHCID 607502—
ProductEthyl 2-methyl-2-[4-(6-chloroquinolin-2-yloxy)phenoxy]-propionateHCID 20461951—

Reaction Steps

Ethyl 2-methyl-2-[4-(6-chloroquinolin-2-yloxy)phenoxy]-propionate (36) was prepared from 2,6-dichloroquinoline and ethyl 2-methyl-2-(4-hydroxyphenoxy)propionate following essentially the same procedure as that described in Example 1. The product was isolated after chromatography as a low melting point solid. Mass spectrum (m/e): 385 (parent ion; 30%); 312 (35%); 271 (100%); 270 (100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04444584
Source datasetuspto-grants-1984_04
ORD IDord-1a94effe0ac8457cbaabccc480144319
Source noteuspto-grants-1984_04