HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 1-(5-Fluoro-2-nitrophenyl)piperidine | HCID 53256708 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine | HCID 68680582 | 100% |
Reaction Steps
A solution of 1-(5-fluoro-2-nitro-phenyl)-piperidine (200 mg, 0.89 mmol) in 4 mL of 2M methylamine in MeOH was heated in a sealed tube for 12 h at 80° C. Removal of the solvent under vacuum afforded methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine (209 mg, 100%). Mass spectrum (ESI, m/z): Calcd. for C12H17N3O2, 236.1 (M+H), found 236.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427683B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-35df5273ff394d5f9a43343c78f31b88 |
| Source note | uspto-grants-2008_09 |