HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2,6-Dimethoxymethyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | o-(Trifluoromethyl)benzaldehyde | HCID 123067 | — |
| Reactant | Ethyl 4-methoxy-3-oxobutanoate | HCID 12645099 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,6-Dimethoxymethyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 68120665 | 60% |
Reaction Steps
8.7 g of 2-trifluoromethylbenzaldehyde, 16 g of γ-methoxyacetoacetic acid ethyl ester and 5 ml of aqueous concentrated ammonia in 30 ml of ethanol are heated to the boil overnight, the mixture is cooled and 2,6-dimethoxymethyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of light brown crystals of melting point 133°-134° C, in a yield of 60% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04020178 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-01cebe59d39643879ccafae18a14e7aa |
| Source note | uspto-grants-1977_04 |