HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → N-((4-(Benzyloxy)phenyl)(tosyl)methyl)formamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | p-Toluenesulfinic acid | HCID 10818 | — |
| Reactant | Benzaldehyde, 4-(phenylmethoxy)- | HCID 78109 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-((4-(Benzyloxy)phenyl)(tosyl)methyl)formamide | HCID 59797510 | 49% |
Reaction Conditions
| Temperature | 60 °C |
|---|
Reaction Steps
A mixture of 4-methylbenzenesulfinic acid (3.1 g, 19.9 mmol), 4-(benzyloxy)benzaldehyde (4.2 g, 19.9 mmol), and formamide (4.5 mL ) was heated at 60° C. for 20 h. The mixture was diluted with methanol and stirring was continued for 1 h at rt. The resultant solid was filtered and dried to give 3.81 g (49%) of a white solid. The product was used in the next step without future purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429665B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-89e71a12bdda428480b51ec0550a9332 |
| Source note | uspto-grants-2008_09 |