HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(6-Methoxy-1,3-benzothiazol-2-yl)aniline → 3-Trifluoromethyl-N-[4-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]-4-(methoxy)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(6-Methoxy-1,3-benzothiazol-2-yl)aniline | HCID 391870 | — |
| Reactant | 4-Methoxy-3-(trifluoromethyl)benzoyl chloride | HCID 2775298 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-Trifluoromethyl-N-[4-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]-4-(methoxy)benzamide | HCID 67313154 | 87% |
Reaction Steps
Prepared as described in the Amide Coupling section using 2-(4-aminophenyl)-6-methoxybenzothiazole (0.5 g, 1.95 mmol) and 4-methoxy-3-trifluoromethylbenzoyl chloride (0.47 g, 1.95 mmol) in dry pyridine (15 ml) to give the title compound (0.77 g, 87%) as pale yellow feathery crystals after work-up and recrystallisation from acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895313B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-f231a315b48e409ca85777f2f217b6a9 |
| Source note | uspto-grants-2014_11 |