HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (S)-methyl 2-amino-4-bromobutanoate hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Amino-4-bromobutanoic acid hydrobromide | HCID 13877992 | — |
| Product | (S)-methyl 2-amino-4-bromobutanoate hydrobromide | HCID 42614181 | — |
Reaction Steps
SOCl2 (7.0 mL) was added slowly to MeOH (100 mL) at −20° C. (bath temp), and stirred for 30 min. 2-Amino-4-bromo-butyric acid hydrobromide (5.0 g, 19 mmol) was then added and the reaction mixture was stirred O/N at rt. Concentration in vacuo gave the title compound as a viscous liquid which become solid on standing: yield 5.2 g (99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895534B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-d365ffcd5e9f410aa50b422a0e3db08c |
| Source note | uspto-grants-2014_11 |