HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3,4,5-tetrahydro-1H-1-benzazepine → 1-(4-Cyano-2-methylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3,4,5-tetrahydro-1H-1-benzazepine | HCID 576503 | — |
| Reactant | 4-Cyano-2-methylbenzoic acid | HCID 11819339 | — |
| Product | 1-(4-Cyano-2-methylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine | HCID 21083237 | — |
Reaction Steps
The carboxylic acid from Example D (0.96 g, 5.95 mmol) was reacted with 2,3,4,5-tetrahydro-1H-1-benzazepine (0.80 g, 5.44 mmol) according to the procedure in Example 1A. The product was purified by flash chromatography on silica (eluant EtOAc:pet. ether 30:70); yield 0.59 g (38%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176195B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-b06e9397f68f49559e1e2e78bfa0ac13 |
| Source note | uspto-grants-2007_02 |