HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S)-1-phenylpropan-1-amine → (S)-N-(alpha-Ethylbenzyl)-3-methyl-7-methoxy-2-phenylquinoline-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S)-1-phenylpropan-1-amine | HCID 6993773 | — |
| Reactant | 3-Methyl-7-methoxy-2-phenylquinoline-4-carbonylchloride | HCID 22714324 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-N-(alpha-Ethylbenzyl)-3-methyl-7-methoxy-2-phenylquinoline-4-carboxamide | HCID 53800998 | — |
Reaction Steps
Prepared as described in Ex. 1, starting from 1.27 g (4.09 mmol) of crude 3-methyl-7-methoxy-2-phenylquinoline-4-carbonylchloride, 0.55 g (4.09 mmol) of (S)-(−)-α-ethylbenzylamine and 1.71 ml (12.27 mmol) of TEA in 24 ml of dry CH2Cl2 and 1 ml of DMF to help solubility. The reaction mixture was stirred 12 hours at room temperture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743804B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-6b6d42c8181744128124c7ceaab1b7a8 |
| Source note | uspto-grants-2004_06 |