HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-5-methylisoxazole → 5,6-Dihydro-4-hydroxy-2,6-dimethyl-N-(5-methyl-3-isoxazolyl)-1,1-dioxo-2H-1,2,6-thiadiazine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-5-methylisoxazole | HCID 66172 | — |
| Reactant | methyl 5,6-dihydro-4-hydroxy-2,6-dimethyl-1,1-dioxo-2H-1,2,6-thiadiazine-3-carboxylate | HCID 54719676 | — |
| Product | 5,6-Dihydro-4-hydroxy-2,6-dimethyl-N-(5-methyl-3-isoxazolyl)-1,1-dioxo-2H-1,2,6-thiadiazine-3-carboxamide | HCID 54719677 | 49% |
Reaction Steps
The synthesis was effected analogously to Example 1 using in each case 1.0 equivalent of methyl 5,6-dihydro-4-hydroxy-2,6-dimethyl-1,1-dioxo-2H-1,2,6-thiadiazine-3-carboxylate and 3-amino-5-methylisoxazole. Recrystallisation from a diisopropyl ether/tetrahydrofuran mixture gives the title compound in a yield of 49%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05411955 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-08f064fa14be4ae4821b076e7a759930 |
| Source note | uspto-grants-1995_05 |