HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Pyridine-3,5-dicarboxylic acid methyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3,5-Pyridinedicarboxylic acid | HCID 10366 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Product | Pyridine-3,5-dicarboxylic acid methyl ester hydrochloride | HCID 70274642 | — |
Reaction Steps
Pyridine-3,5-dicarboxylic acid (5.00 g, 29.9 mmol) was stirred in CH3OH (100 mL), cooled in an ice bath, and treated dropwise with thionyl chloride (17.45 mL, 239.2 mmol). After 0.5 hr, the reaction mixture was refluxed for 48 hrs. Concentration to dryness gave the title compound as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127366 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-1b62a4aa5e3545ef8cc070eb914f7418 |
| Source note | uspto-grants-2000_10 |