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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 37166Generated: October 24, 2026

1-(Bis(4-fluorophenyl)methyl)piperazine → 6-Hydroxy-2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-2,3-dihydro-1,4-benzodioxin

https://huagongshe.com/en/reaction/37166

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bis(4-fluorophenyl)methyl)piperazineHCID 152932—
Reactant6-Hydroxy-2,3-dihydro-1,4-benzodioxin-2-carboxylic acidHCID 10878062—
Product6-Hydroxy-2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-2,3-dihydro-1,4-benzodioxinHCID 1176239380%

Reaction Steps

That compound is obtained a yield of 80% starting from 1-[bis(4-fluorophenyl)methyl]piperazine and 6-hydroxy-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05420132
Source datasetuspto-grants-1995_05
ORD IDord-f5a152932e154c3bae7a278924305675
Source noteuspto-grants-1995_05