HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethyl 3-methoxyphenyl ketone → 3-Amino-6-chloro-1-ethoxycarbonyl-2-(3-methoxybenzoyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethyl 3-methoxyphenyl ketone | HCID 101294 | — |
| Reactant | 4-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile | HCID 18367888 | — |
| Product | 3-Amino-6-chloro-1-ethoxycarbonyl-2-(3-methoxybenzoyl)indole | HCID 18367743 | — |
Reaction Steps
The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 2-bromo-3′-methoxyacetophenone. 1H-NMR (CDCl3) δ: 8.25 (1H, d, J=1.5 Hz), 7.53 (1H, d, J=8.4 Hz), 7.36-7.26 (4H, m), 7.05-7.01 (1H, m), 5.78 (2H, s), 3.84 (3H, s), 3.78 (2H, q, J=7.0 Hz), 0.89 (3H, t, J=7.0 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06300363B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-d24454c6e5304e5f9b22cf3e4a6e9acb |
| Source note | uspto-grants-2001_10 |