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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 389921Generated: October 24, 2026

Benzilic acid → (1r/s,3r)-3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-methyl-1-(pyrazin-2-yl-carbamoyl-methyl)-pyrrolidinium bromide

https://huagongshe.com/en/reaction/389921

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzilic acidHCID 6463—
ReactantHCID 131730243HCID 131730243—
Product(1r/s,3r)-3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-methyl-1-(pyrazin-2-yl-carbamoyl-methyl)-pyrrolidinium bromideHCID 131730257—

Reaction Steps

This compound is prepared by an analogous method to (1R/S,3R)-3-((R/S)-(2-cyclohexyl-2-hydroxy-2-phenyl-acetoxy)-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-pyrrolidinium bromide (Example 1) by replacing cyclohexyl-hydroxy-phenyl-acetic acid with benzilic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08383625B2
Source datasetuspto-grants-2013_02
ORD IDord-8332f730aa044703b7b98fdd89ac44b8
Source noteuspto-grants-2013_02