5'-Chloro-2,2'-bithiophene-5-sulfonyl chloride → 5'-Chloro-[2,2']bithiophenyl-5-sulfonic acid [2-oxo-1-(1H-pyrrolo[3,2-c]pyridin-2-ylmethyl)-pyrrolidin-3(S)-yl]-amide

Participants

Reaction Steps

The title compound is prepared as described in EXAMPLE 56, Part A using 5′-chloro-[2,2′]bithiophenyl-5-sulfonyl chloride and 2-[3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester as starting material. The crude product can be purified by column chromatography eluting with 5% MeOH/CH2Cl2to give the title compound as a white solid or used in the subsequent step after an aqueous work-up without further purification. Ion spray MS, [M+H]+=593, 595, Cl pattern.

Provenance & Evidence