HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-(trifluoromethyl)benzaldehyde → 4-{8-[4-Chloro-3-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-(trifluoromethyl)benzaldehyde | HCID 118642 | — |
| Reactant | 4-{2-Oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-ylbenzoic acid hydrochloride | HCID 66764696 | — |
| Product | 4-{8-[4-Chloro-3-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid | HCID 86685275 | — |
Reaction Steps
The title compound was prepared from 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoic acid hydrochloride salt (20 mg, 0.064 mmol; Example 5-1, Step 4) and 4-chloro-3-trifluoromethylbenzaldehyde (14.68 mg, 0.071 mmol), following essentially the same procedure described in Example 7-1. The title compound was obtained as a white solid (17.4 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08742110B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-2e1a610964984156a708fc3ae721feae |
| Source note | uspto-grants-2014_06 |