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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404053Generated: October 23, 2026

Methyl D-valinate hydrochloride → (R)-Methyl 3-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)butanoate

https://huagongshe.com/en/reaction/404053

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl D-valinate hydrochlorideHCID 11984198—
ReactantMethyl 4-(bromomethyl)-4'-nitrobiphenyl-3-carboxylateHCID 67306641—
Reactant(S)-Methyl 3-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)butanoateHCID 131731440—
Product(R)-Methyl 3-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)butanoateHCID 13173158177%

Reaction Steps

The compound of example 538 was prepared analogous to compound of example 5 by reaction of compound of example 4 with D-valine methyl ester hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748426B2
Source datasetuspto-grants-2014_06
ORD IDord-9d2438bd1233441db0ab6d10395d4eda
Source noteuspto-grants-2014_06