Iodoethanol → 5-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one

HRID 406761

Reaction equation

[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.I[CH2:10][CH2:11][OH:12]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[N:6]([CH2:10][CH2:11][OH:12])[CH:7]=1

Participants

Reactant 2

HCID 12225Iodoethanol

HCID 5995285-Bromo-2-hydroxypyridine

Product 1

HCID 434194335-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one

Procedure

5-Bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one was prepared from 5-bromopyridin-2(1H)-one and 2-iodoethanol following a procedure analogous to that described in Example 20 Step 1.

Sources & evidence

ORD record: ord-db4f32b4599945908b53f2195ee0a01e
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08754076B2

Linked notes

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