HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40750Generated: October 23, 2026
4-Piperidinecarboxylic acid → 1-(3-Bromo-5-cyanophenyl)piperidine-4-carboxylic acid
https://huagongshe.com/en/reaction/40750
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | 3-Bromo-5-fluorobenzonitrile | HCID 2783330 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(3-Bromo-5-cyanophenyl)piperidine-4-carboxylic acid | HCID 59588189 | — |
Reaction Steps
A mixture of 3-bromo-5-fluorobenzonitrile (1.6 g, 7.8 mmol), piperidine-4-carboxylic acid (2.6 g, 12.0 mmol), triethylamine (4.0 mL, 28.5 mmol) and N,N-dimethylacetamide (1.5 mL) in a sealed tube was heated to 130° C. for 48 hr. The reaction mixture was diluted with EtOAc and water. The organic layer was separated, dried (MgSO4), and concentrated to give a crude reside which was purified by chromatography on silica gel (CH2Cl2/MeOH) to afford 1-(3-bromo-5-cyanophenyl)piperidine-4-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08530480B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-1e41f83bd2d044c3bbd5d6d755aa169b |
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| Source note | uspto-grants-2013_09 |
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