HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42213Generated: October 24, 2026
Triethylamine → 1-Benzyl-4-[4-(5-nitro-pyridin-2-yl)-piperazin-1-yl]-phthalazine
https://huagongshe.com/en/reaction/42213
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Reactant | 1-Benzyl-4-piperazin-1-yl-phthalazine | HCID 6404023 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Benzyl-4-[4-(5-nitro-pyridin-2-yl)-piperazin-1-yl]-phthalazine | HCID 59240646 | 70% |
Reaction Steps
1-Benzyl-4-piperazin-1-yl-phthalazine (500 mg, 1.64 mmol) and 2-chloro-5-nitropyridine are combined in a 10 mL microwave vial. Triethylamine (2.96 mL, 2.14 mmol) and NMP (4.8 mL) are added. The vial is sealed and heated to 180° C. for 15 min. The crude reaction mixture is poured into water and the resulting precipitate is isolated by filtration to afford the title compound (500 mg, 70% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08536168B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-b9412275fd54459e8003c8a420857e7d |
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| Source note | uspto-grants-2013_09 |
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