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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43349Generated: October 24, 2026

4-(Trifluoromethyl)aniline → 1-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidine

https://huagongshe.com/en/reaction/43349

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)anilineHCID 9964—
Reactanttert-Butyl 4-oxopiperidine-1-carboxylateHCID 735900—
Product1-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidineHCID 22029142—

Reaction Steps

The title compound was prepared from 1,1-dimethylethyl 4-oxo-1-piperidinecarboxylate and 4-trifluoromethylaniline using a method similar to that described for D20

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536182B2
Source datasetuspto-grants-2013_09
ORD IDord-0cdf9bad8f684c969d72ef5d723d76a0
Source noteuspto-grants-2013_09